Personalised testosterone replacement therapy, built around your biology.
Your TRT. Your protocol. Not a template.
Most testosterone replacement therapy in the UK operates on the same starting dose, the same delivery method, and the same monitoring schedule for every patient. It works for some men. For many others, it means months of adjustment to find what should have been right from the start.
Arc TRT does it differently. We design your testosterone therapy around your bloods, your symptoms, your lifestyle and your DNA. Doctor-led, evidence-based, and built to make you feel right the first time — not after six months of trial and error.
Testosterone replacement therapy (TRT) in the UK, explained
Testosterone replacement therapy, usually shortened to TRT, is a long-term medical treatment for men with clinically low testosterone (also called testosterone deficiency or male hypogonadism). It works by replacing the testosterone your body is no longer producing in sufficient amounts, restoring levels to a healthy physiological range.
In the UK, TRT is available privately through specialist clinics and, in some cases, through the NHS. Private testosterone replacement therapy typically offers faster diagnosis, more thorough testing, and access to modern dosing protocols that the NHS doesn't always provide. UK clinical practice follows guidance from the British Society for Sexual Medicine (BSSM), with treatment generally considered for men with bothersome symptoms and a total testosterone below 12 nmol/L confirmed across two blood tests.
When TRT is properly prescribed and monitored, it can resolve symptoms that have often been present for years: persistent fatigue, brain fog, low mood, reduced libido, erectile difficulties, loss of muscle, increased body fat, and disturbed sleep. The key word, though, is properly. Not all UK TRT is built the same way.
"Personalised" testosterone replacement therapy usually means template-based
Walk into ten UK clinics offering testosterone replacement therapy with the same low testosterone result and most of them will give you a similar starting protocol. Same dose. Same injection schedule. Same monitoring intervals. Same plan to "see how you respond."
That isn't personalised care. That's template-based testosterone therapy with a customer service layer. And when men struggle to feel right on TRT, this is almost always why.
Template-based testosterone therapy, adjusted reactively
- Standard starting dose applied to everyone
- Delivery method chosen based on availability, not biology
- Same monitoring schedule for every patient
- Side effects managed after they appear
- Oestrogen, DHT, haematocrit issues handled when they become problems
- Adjustments made over months of trial and error
Testosterone replacement therapy designed around your biology
- Starting dose informed by your bloods, body composition and genetics
- Delivery method chosen for how your body absorbs and metabolises
- Monitoring schedule tailored to your individual risk profile
- Side effect risks anticipated before they appear
- Oestrogen and DHT managed proactively where genetics indicate
- Right protocol from the start, not after six months of adjustment
Five things that make your TRT genuinely personal
Personalised TRT isn't a marketing word for us. It's how we structure every treatment plan. Here are the five biological factors we use to build your protocol.
Comprehensive baseline testing
Most clinics test total testosterone. We go further. Total and free testosterone, SHBG, LH, FSH, oestradiol, prolactin, full blood count, thyroid function, lipids, glucose, PSA, and liver and kidney markers — all at baseline.
Why it matters: a 30-year-old with the testosterone level of a 70-year-old can still come back "in range" on a basic test. The full panel tells us what's actually going on.
What's actually bothering you
Two men with identical testosterone levels can present completely differently. One has fatigue and brain fog as primary complaints. Another has loss of libido and erectile difficulties. A third has mood changes and motivation drops.
Your symptom pattern shapes which markers we prioritise tracking, which side effects we monitor most closely, and how we measure whether treatment is working.
Genetic markers that predict response
DNA testing for TRT response examines variants in genes that determine how you metabolise testosterone, your aromatase activity (testosterone-to-oestrogen conversion), your 5-alpha reductase activity (DHT conversion, hair loss risk), and your androgen receptor sensitivity.
This isn't standard across UK TRT providers. It's one of our genuine differentiators. It lets us anticipate how your body will respond rather than discover it through trial and error.
Body composition, training, and goals
A man with significant excess weight has different aromatase activity to one who's lean. A man who trains heavily has different recovery and protein demands. A man with a young family planning more children has different fertility considerations.
Your protocol accounts for who you actually are, not the average TRT patient on paper. Weight loss medication, hair loss prevention and fertility support all sit alongside testosterone therapy when they're clinically relevant.
Clinical decisions, not algorithms
The data informs the plan. Your doctor makes the plan. Every protocol at Arc TRT is reviewed and prescribed by a UK GMC-registered doctor — not a pharmacist following a template, not an algorithm scoring you out of ten.
Led by Dr Chris Airey (GMC 7490533) and Dr Lauren Airey (GMC 7559644), our clinical team's full attention is on TRT and the conditions around it.
A protocol that fits the first time
When these five inputs are properly considered before treatment begins, most men feel substantially better within the first six to twelve weeks. Not after a year of adjustments.
That's the difference personalisation actually makes.
"We treat the patient, not the number on the paper. Two men with the same testosterone level can need entirely different protocols. The job of a TRT doctor is to figure out which is which."
Your personalised TRT journey, step by step
Personalised care isn't just what's in your prescription. It's how the whole treatment is structured around you.
Comprehensive blood test
An at-home finger-prick test that covers far more than total testosterone. The first piece of data we use to understand your hormonal picture.
Doctor review and consultation
Your bloods, your symptoms and your goals reviewed by a UK GMC-registered doctor. Not a template, not an algorithm — a clinical conversation about what's actually going on.
Optional DNA testing
Where it adds clinical value, we run genetic testing to predict your response to testosterone therapy. Aromatase activity, DHT conversion, androgen receptor sensitivity — all baked into the protocol from day one.
Confirmatory test and protocol design
A second blood test confirms the picture. Your doctor then designs your protocol — dose, delivery method, monitoring schedule, adjunct treatments — built around your specific biology.
Treatment begins
You start your protocol with full instruction. Your treatment coordinator is your single point of contact for any questions throughout your journey.
Early review and refinement
A follow-up review with repeat bloods at six weeks. We refine the protocol based on how your body has actually responded — not a generic timeline.
Ongoing personalised monitoring
Quarterly to half-yearly bloodwork, with monitoring intervals adjusted based on your individual risk profile. Where adjunct treatments are part of your plan, they're managed by the same clinical team.
Built on four years of UK TRT experience
Personalised care extends beyond testosterone
Low testosterone rarely arrives alone. Many men we treat are also dealing with stubborn weight that won't shift, accelerating hair loss they hadn't expected, or uncertainty about how their body will respond to therapy.
A truly personalised TRT plan accounts for all of this. Our integrated adjunct treatments sit alongside your testosterone protocol where they're clinically appropriate.
- Weight loss support — GLP-1 medications integrated with TRT where excess weight is contributing to hormonal imbalance
- Hair loss prevention — finasteride and minoxidil protocols for men genetically predisposed to male pattern baldness
- DNA testing — for treatment response, hair loss risk, and metabolic profile
Frequently asked questions about TRT in the UK
Testosterone replacement therapy (TRT) is a long-term medical treatment that replaces testosterone in men whose bodies are no longer producing enough of it. In the UK, TRT is available privately through specialist clinics and, in some cases, through the NHS. UK clinical practice follows BSSM guidance, with treatment generally considered for men with bothersome symptoms and a total testosterone below 12 nmol/L confirmed across two blood tests.
Standard TRT typically uses a template starting dose and adjusts based on how you respond over months. Personalised TRT uses your comprehensive bloods, symptoms, lifestyle and (optionally) genetic information to design your protocol around your biology from day one. The aim is to land on the right protocol the first time rather than discover it through trial and error.
TRT is for men with clinically low testosterone alongside bothersome symptoms. Common symptoms include persistent fatigue, brain fog, low libido, erectile difficulties, reduced motivation, increased body fat, loss of muscle and poor sleep. A proper assessment looks at both your bloods and your symptoms — neither alone is enough to make a diagnosis. Testosterone replacement therapy is not appropriate for men with normal testosterone levels seeking enhancement rather than treatment.
It isn't strictly necessary. Many men do well on TRT without it. Where DNA testing adds genuine value is for men who've tried TRT before and struggled to find the right protocol, men with complex pictures (significant weight to lose, family history of hair loss, fertility concerns), or men who want the most clinically advanced approach available. We don't require it for every patient.
Most men feel measurable improvements within six to twelve weeks. Energy levels, mood and libido typically respond first. Body composition changes (muscle, fat distribution) typically take longer, often three to six months. The advantage of personalisation is reducing the time spent adjusting away from a generic starting point.
Comprehensive bloodwork, doctor consultation, prescription medication, ongoing monitoring at the intervals your protocol requires, access to your treatment coordinator, and clinical reviews throughout treatment. Adjunct treatments (weight loss support, hair loss prevention, DNA testing) are available where clinically relevant. Full pricing is published transparently on our pricing page.
Yes. We can review your existing protocol, recent bloodwork and treatment history, and design a personalised plan that builds on what's working and changes what isn't. Many of our patients come to us after struggling to feel right on template-based protocols elsewhere.
Yes. Arc TRT operates under full Care Quality Commission (CQC) regulation, with GMC-registered UK doctors leading clinical decisions and a GPhC-registered pharmacy handling prescriptions. We follow BSSM (British Society for Sexual Medicine) guidelines for TRT diagnosis and treatment.
Ready for testosterone replacement therapy that's actually built around you?
It starts with information. A home blood test, reviewed by one of our UK doctors, tells us whether TRT is right for you and gives us the first piece of data we'll use to design your personalised plan.
Order a blood test →Or speak to our team →